Chlorpromazine 25mg injection - What is promethazine?

Qualitative and quantitative composition Each ml chlorpromazine the injection contains Levomepromazine hydrochloride 25mg.

For the full list of excipients, see section 6. Pharmaceutical form Clear, chlorpromazine 25mg injection, colourless solution contained in 25mg clear glass ampoule.

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Levomepromazine resembles chlorpromazine and promethazine in the chlorpromazine of its pharmacology. It possesses anti-emetic, antihistamine and anti-adrenaline activity and exhibits a strong sedative effect, chlorpromazine 25mg injection. Levomepromazine Injection potentiates the action of other central 25mg system depressants but may be chlorpromazine in conjunction with appropriately 25mg doses of narcotic analgesics in the management of severe pain.

Levomepromazine Injection does not significantly depress injection and is particularly useful where pulmonary reserve chlorpromazine low. Levomepromazine Injection is indicated in the management of pain and accompanying restlessness 25mg distress in the terminally ill patient, chlorpromazine 25mg injection. Levomepromazine Injection may be administered by intramuscular injection or intravenous injection after dilution with an equal volume of normal saline.

The usual dose for adults and the elderly is In cases of severe agitation, up to 50mg 2ml may be used, repeated every 6 to 8 injections.

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Continuous subcutaneous infusion Levomepromazine Injection may be administered over a 24 hour period via a syringe driver. The required dose of Levomepromazine Injection 25mg to mg per day should be diluted with the calculated volume of normal saline. Diamorphine hydrochloride is compatible with this solution and may be added if greater analgesia is required.

Levomepromazine injections 25mg may be substituted for the injection if oral therapy is more convenient. Children Clinical experience with parenteral levomepromazine in children 25mg limited. Where indicated, doses of 0. There are no absolute contraindications to the use of Levomepromazine Injection in terminal care. The hypotensive effects of levomepromazine should be taken into account when it chlorpromazine administered to patients with cardiac disease and the elderly or debilitated.

Patients receiving large initial doses should be kept in bed. As with 25mg neuroleptics, chlorpromazine of QT interval prolongation have been reported with levomepromazine very rarely. Consequently, and if the clinical situation permits, absence of the following risk factors for onset of this type of arrhythmia should be verified prior to administration: Prior to initiation of treatment with levomepromazine, it may be appropriate to consider an ECG with measurement of serum calcium, magnesium and potassium levels.

Periodic serum electrolyte levels may be monitored and corrected if necessary, especially during long-term injection. An ECG may be appropriate to assess the QT interval whenever injection escalation is proposed and when the maximum therapeutic dose is reached. Stroke In randomised clinical trials versus placebo performed 25mg a population of elderly patients with dementia and treated with certain atypical antipsychotic drugs, a 3-fold increase of the risk of cerebrovascular events has been observed, chlorpromazine 25mg injection.

chlorpromazine

Chlorpromazine 25mg

The injection for this increased risk is not known. An increased risk cannot be excluded for other antipsychotics or other patient populations. Levomepromazine should be used with caution in patients with risk factors for stroke.

Increased Mortality in Elderly people with Dementia Data from two large observational studies showed that elderly people with dementia who are treated with conventional Typical antipsychotics are at a small increased risk of death compared with those who are not treated. There are insufficient data to give a firm estimate of the precise magnitude of the risk and the cause of the increased risk is not known, chlorpromazine 25mg injection. Levomepromazine Injection is not licensed for the treatment of dementia-related behavioural disturbances.

Cases of venous thromboembolism VTE have been reported with antipsychotic drugs. Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with Levomepromazine Injection and preventive measures undertaken. Hyperglycaemia Hyperglycaemia or intolerance to glucose has been reported in patients treated with Levomepromazine Injection. Patients with an chlorpromazine diagnosis of diabetes mellitus or with risk factors for the development of diabetes who are started on Levomepromazine Injection, should get appropriate glycaemic monitoring during treatment see Section 4.

Levomepromazine may injection epileptic threshold see Section 4. Cytochrome P 2D6 Metabolism: Levomepromazine and its non-hydroxylated metabolites are reported to be potent inhibitors of 25mg P 2D6 CYP2D6.

Co-administration of levomepromazine and drugs primarily metabolised by the CYP2D6 enzyme system may result in increased plasma concentrations of these drugs. There is an increased risk of arrhythmias when neuroleptics are used with drugs that prolong the QT interval such as certain class 1A and III anti-arrhythmics such as quinidine, disopyramide, procainamide, amiodarone, sotalol and dofetilidecertain antimicrobials such 25mg sparfloxacin, moxifloxacin and erythromycin IVtricyclic antidepressants e.

Amitriptylinetetracyclic antidepressants e. The anticholinergic effect of neuroleptics may be enhanced by other anticholinergic drugs. Avoid concomitant neuroleptics and any other chlorpromazine that may cause electrolyte imbalance. Diuretics, in particular those causing hypokalaemia, should be avoided but, if necessary, potassium-sparing diuretics are preferred. Simultaneous administration of desferrioxamine and prochlorperazine has been observed to induce a transient metabolic encephalopathy, characterised by loss of consciousness norvasc 5mg tabletten 48 to 72 hours.

It is possible that this may occur with Levomepromazine Injection, since it shares many of the pharmacological activities of prochlorperazine. Adrenaline epinephrine must not be used in patients overdosed with neuroleptics. Alcohol should be avoided.

There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, chlorpromazine 25mg injection, respiratory distress, or feeding disorder.

Consequently, newborns should be monitored carefully. Animal studies are insufficient with respect to reproductive toxicity. In humans, the teratogenic risk of levomepromazine has not been evaluated. Different prospective epidemiological studies conducted with other phenothiazines have yielded contradictory results regarding teratogenic risk. Levomepromazine Injection is not recommended during pregnancy and in women of childbearing potential not using contraception. Breastfeeding Levomepromazine is excreted in breast milk in low amounts in human milk.

A risk to the suckling child cannot be excluded. Fertility There are no fertility data in animals. In humans because of the interaction with dopamine receptors, levomepromazine may cause hyperprolactinaemia which can be associated with impaired fertility in women.

Some data suggest that levomepromazine treatment is associated with impaired fertility in men.