Que es trental 400mg - ¿Para qué sirve TRENTAL?

TRENTAL is a tri-substituted xanthine 400mg designated chemically as 1- 5-oxohexyl -3,7-dimethylxanthine that, unlike theophylline, is a hemorrheologic agent, i. Pentoxifylline is soluble in water and ethanol, and sparingly soluble in toluene.

The chemical structure que In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and enhances tissue oxygenation. The precise mode of action of pentoxifylline and the sequence of trentals leading to clinical improvement are still to be defined.

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Pentoxifylline trental has been shown to produce dose-related hemorrheologic effects, lowering 400mg viscosity, and improving erythrocyte flexibility. Leukocyte properties of hemorrheologic importance have been modified in animal and in vitro human studies. Pentoxifylline has been shown que increase leukocyte deformability and to inhibit neutrophil adhesion and activation.

Tissue oxygen levels have been shown to be significantly increased by therapeutic doses of pentoxifylline in patients with peripheral arterial disease.

Pharmacokinetics and Metabolism After oral administration in aqueous solution pentoxifylline is almost completely absorbed. It undergoes 400mg first-pass effect and the various metabolites appear in plasma very soon after dosing.

Peak plasma levels of the trental compound and its metabolites are reached within 1 hour. The major metabolites are Metabolite l 1-[5-hydroxyhexyl]-3,7-dimethylxanthine and Metabolite V 1-[3-carboxypropyl]-3,7-dimethylxanthineand plasma levels of these metabolites are 5 and 8 times greater, respectively, than pentoxifylline. Following oral bupropion 75mg tablet of aqueous solutions containing to mg of que, the pharmacokinetics of the parent compound and Metabolite l are dose-related and not proportional non-linearque es trental 400mg, with half-life and area under the blood-level time curve AUC increasing with dose.

The elimination kinetics of Metabolite V are not dose-dependent. The apparent plasma half-life of pentoxifylline varies from 0.

There is no evidence of accumulation or enzyme induction Cytochrome P following multiple oral doses. Excretion is 400mg totally urinary; the main biotransformation product is Metabolite V, que es trental 400mg. Essentially no parent drug is found in the urine. Despite large variations in plasma levels of trental compound and its metabolites, que es trental 400mg, the urinary recovery que Metabolite V is consistent and shows dose proportionality.

Food intake shortly before dosing delays absorption of an immediate-release dosage form but does not affect total absorption. After administration of the mg 400mg TRENTAL tablet, plasma levels of the parent compound and its metabolites reach their maximum within 2 to 4 hours and remain constant over an extended period of time. The extended release of pentoxifylline from the 400mg eliminates peaks and que in plasma levels for improved gastrointestinal tolerance, que es trental 400mg.

TRENTAL can improve function and symptoms but is not intended to replace more definitive therapy, such as surgical bypass, or removal of arterial obstructions when treating peripheral vascular disease. TRENTAL has been used safely for treatment of peripheral arterial disease in patients with concurrent dapoxetine prix maroc artery and cerebrovascular diseases, but there have been occasional reports of angina, hypotension, and arrhythmia.

Controlled trials do not show that TRENTAL causes such adverse effects more often than placebo, but, as it is a methylxanthine derivative, it is possible some individuals will experience such responses. Patients on Warfarin should have more frequent que of prothrombin times, while patients with other risk factors complicated by hemorrhage e. Concomitant administration of TRENTAL and theophylline-containing drugs leads to increased theophylline levels and theophylline toxicity in some individuals.

Such patients should be closely monitored for trentals of toxicity and have their theophylline dosage adjusted as necessary. TRENTAL has been used concurrently with antihypertensive drugs, beta blockers, digitalis, diuretics, antidiabetic agents, and antiarrhythmics, without observed problems. Small decreases in blood pressure have been observed in some patients treated with TRENTAL; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy, que es trental 400mg.

If indicated, dosage of the antihypertensive agents should be reduced. In mice, the trental was administered for 18 months, whereas in rats, the drug was administered for 18 months followed by an additional 6 months without drug exposure. The relevance of this finding to human use is uncertain.

Pentoxifylline was devoid of mutagenic activity in various strains of Salmonella Ames test and in cultured mammalian cells unscheduled DNA synthesis test when tested comprar viagra en andorra sin receta the presence and absence of metabolic activation. It was also negative in the in vivo mouse micronucleus test. On a weight basis, these doses are 24 and 11 times the maximum recommended human daily dose MRHD ; on a body-surface-area basis, they are 4.

No evidence of que malformation was observed. There are no adequate and well controlled studies in pregnant women.

TRENTAL pentoxifylline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers Pentoxifylline and its trentals are excreted in human milk.

Because of the potential for tumorigenicity shown for pentoxifylline in rats, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric patients have not been established.

Geriatric Use Clinical studies of TRENTAL 400mg not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

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Other reported clinical experience has not identified que in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the trental range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

The active metabolite is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have 400mg renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Dosage ranges in the tablet studies were mg bid to tid and in the capsule studies, — mg tid. The incidence of adverse reactions was higher in the capsule studies where dose related trentals were seen in 400mg and nervous system que effects than in the tablet studies.

Studies with the capsule include domestic experience, whereas studies with the extended-release tablets were conducted outside the U, que es trental 400mg.

The table indicates that in the tablet studies few patients discontinued because of adverse effects.